LABORATORY
CAO
Publications
Cao X+, Landick R, Campbell EA. A roadmap for designing narrow-spectrum antibiotics targeting bacterial pathogens. Microbial Cell 9 (7), 136. Review Article. +Corresponding author
Cao X*, Boyaci H*, Chen J, Bao Y, Landick R, Campbell EA. Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile. Nature, 604 (7906), 541-545. *Equal contributions
(See here for Research Briefing in Nature)
Malone B, Chen J, Wang Q, Llewellyn E, Choi Y, Dominic P, Olinares B, Cao X, et al. Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex. Proc Natl Sci U S A. 118 (19), e2102516118.
Zhu L, Zou Q, Cao X, Cronan JE. Enterococcus faecalis encodes an atypical auxiliary acyl carrier protein required for efficient regulation of fatty acid synthesis by exogenous fatty acids. mBio. 10 (3), E00577-19.
Cao X*, Hamilton JJ*, Venturelli OS. Understanding and engineering distributed biochemical pathways in microbial communities. Biochemistry. 58 (2), 94-107. Review Article. *Equal contributions
Cao X*, Koch T*, Steffens L, Finkensieper J, Zigann R, Cronan JE, Dahl C. Lipoate-binding proteins and specific lipoate-protein ligases in microbial sulfur oxidation reveal an atypical role for an old cofactor. eLife. doi: 10.7554/eLife.37439. *Equal contributions
Cao X*, Zhu L*, Song X, Cronan JE. Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes. Proc Natl Sci U S A. 115(30): E7063-E7072. *Equal contributions
Hu Z, Dong H, Ma J, Yu Y, Li K, Guo Q, Zhang C, Zhang W, Cao X, Cronan JE, Wang H. A novel xanthomonas campestris long-chain specific 3-oxoacyl-acyl carrier protein reductase involved in diffusible signal factor synthesis. mBio. 9 (3), e00596-18.
Cao X*, Hong Y*, Zhu L, Cronan JE. Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle. Proc Natl Sci U S A. 115(4):647-655. *Equal contributions
Cao X, Zhu L, Hu Z and Cronan J.E., Expression and activity of the BioH esterase of biotin synthesis is independent of genome context. Sci Rep. 7(1):2141.
Shi J*, Cao X*, Chen Y, Cronan JE, Guo Z. An atypical α/β hydrolase fold revealed in the crystal structure of pimeloylacyl carrier protein methyl esterase BioG from Haemophilus influenza. Biochemistry. 55 (48), 6705-6717. *Equal contributions
Cao X and Cronan JE. The Streptomyces coelicolor lipoate-protein ligase is a circularly permuted version of the escherichia coli enzyme composed of discrete interacting domains. J Biol Chem. 290 (11), 7280-7290.
Zhang X, Lu C, Gao M, Cao X, Ha T, Kalbfleisch JH, Williams DL, Li C, Kao RL. Toll-like receptor 4 plays a central role in cardiac dysfunction during trauma hemorrhage shock. Shock. 42(1):31-7.
Cheng YY, Chen Z, Cao X, Ross TD, Falbel TG, Burton BM, Venturelli OS. Programming bacteria for multiplexed DNA detection Nature Communications 14(1) 2001